Human Acid sphingomyelinase (SMPD1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SMPD1
Locus ID	6609
Kit Components	GA104522G1, Acid sphingomyelinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104522G2, Acid sphingomyelinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104522G3, Acid sphingomyelinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000543, NM_001007593, NM_001318087, NM_001318088, NR_027400, NR_134502, NM_001365135
Synonyms	ASM; ASMASE; NPD
Summary	The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]

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