TLR4 Mouse Monoclonal Antibody [Clone ID: 3C3]

Specifications

Product Data
Clone Name	3C3
Applications	FC
Recommend Dilution	Flow cytometry (Typical starting working dilution is 1:50).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	CHO cells expressing chimeric human TLR4/MD-2 fusion protein
Specificity	This antibody reacts with human Toll-like receptor 4 (TLR4, CD284). It is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells.
Formulation	PBS Label: Biotin State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Biotin
Storage Condition	Store at 2 - 8 °C.
Gene Name	toll like receptor 4
Database Link	Entrez Gene 7099 Human UniProt ID O00206
Background	TLRs belong to a family of proteins that specifically recognize and sense microbial products. They are highly conserved throughout evolution. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. TLRs identified as type I transmembrane signalling receptors act as innate immune recognition receptors against many pathogens.TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to LPS of Gram-negative bacteria.
Synonyms	Toll-like receptor 4
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway

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