TLR4 Mouse Monoclonal Antibody [Clone ID: 3C3]
CAT#: AM26183PU-N
TLR4 mouse monoclonal antibody, clone 3C3, Azide Free
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CNY 5,174.00
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Specifications
Product Data | |
Clone Name | 3C3 |
Applications | FC, FN |
Recommend Dilution | Flow cytometry (Typical starting working dilution is 1:50). Functional assays (blocking LPS-induced cytokine functions). |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | CHO cells expressing chimeric human TLR4/MD-2 fusion protein |
Specificity | This antibody reacts with human Toll-like receptor 4 (TLR4, CD284). It is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. |
Formulation | PBS State: Azide Free State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin |
Concentration | lot specific |
Purification | Protein G |
Conjugation | Unconjugated |
Storage Condition | Store at 2 - 8 °C. |
Gene Name | toll like receptor 4 |
Database Link | |
Background | TLRs belong to a family of proteins that specifically recognize and sense microbial products. They are highly conserved throughout evolution. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. TLRs identified as type I transmembrane signalling receptors act as innate immune recognition receptors against many pathogens.TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to LPS of Gram-negative bacteria. |
Synonyms | Toll-like receptor 4 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway |
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