Biosimilars

Biosimilars are biological compounds, almost identical to a reference biologic drug that have been approved by the U.S. Food and Drug Administration for medical treatment. Research-grade biosimilars are research tools for analysis of biological processes without the need to purchase expensive therapeutic-grade biologics.

biosimilars

List of research grade biosimilars

B7-H3 (CD276, Enoblituzumab) CD33 (Gemtuzumab) CD38 (Daratumumab) CD47 (Magrolimab) CD70 (Vorsetuzumab)
ICOS (Vopratelimab) IL3RA (Talacotuzumab) IL6 (Siltuximab) PD1 (PDCD1, Pembrolizumab) PD-L1 (CD274, Atezolizumab)
S Protein (CB6) S Protein (CR3022) SLAMF7 (Elotuzumab) Syndecan 1 (Indatuximab ravtansine) TIM3 (HAVCR2, Cobolimab)

Challenge in biosimilar research: One of the critical challenges in analyzing impact of biosimilars is getting a validated positive control for in-situ analysis. It is especially challenging when these projects involve mutant proteins. Not only is the sample inconsistent in staining but are in short supply.

CytoSections are FFPE sections of HEK293T cell pellet that over-expresses targeted proteins. These cells are obtained by transfection of a sequenced verified cDNA clones transfected into HEK293T cells and the expression is verified by western blot and IHC analysis. Learn more about CytoSections here.

List of other tools for biosimilar research:

Biosimilar Purified Recombinant Protein
(positive control for ELISA) 		CytoSection
(positive control for IHC) 		Additional tools
B7-H3 (CD276)
Enoblituzumab 		Purified protein CytoSection Other research tools
CD33
Gemtuzumab 		Purified protein CytoSection Other research tools
CD38
Daratumumab 		Purified protein CytoSection Other research tools
CD47
Magrolimab 		Purified protein CytoSection Other research tools
CD70
Vorsetuzumab 		Purified protein CytoSection Other research tools
ICOS
Vopratelimab 		Purified protein CytoSection Other research tools
IL3RA
Talacotuzumab 		Purified protein CytoSection Other research tools
PD1 (PDCD1)
Pembrolizumab 		Purified protein CytoSection Other research tools
PD-L1 (CD274)
Atezolizumab 		Purified protein CytoSection Other research tools
CB6 (CR3022)
S Protein 		Purified protein Other research tools
SLAMF7
Elotuzumab 		Purified protein CytoSection Other research tools
Syndecan 1
Indatuximab Ravtansine 		Purified protein CytoSection Other research tools
TIM3
Cobolimab 		Purified protein CytoSection Other research tools