Cervical Cancer

Cervical cancer is the fourth most common cancer found in women globally, and it's primarily caused by persistent high-risk HPV infection. Cervical cancer, which develops in the tissues of the cervix, can be classified into two types: squamous cell carcinoma and adenocarcinoma. Several studies have led to the discovery of a range of biomarkers, including several polymorphisms, microRNAs, mRNA, and serum biomarkers. OriGene offers antibodies, plasmids, and recombinant proteins for the most prominent cervical cancer biomarkers.

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Potential biomarkers ^{1, 2, 3, 4}

Key genes mutated in cervical cancer ⁵

Other genes

One of the challenges in cervical cancer is to distinguish between squamous cell carcinoma (SCC) from adenocarcinoma (AEC) ⁶ In a recent study, Li et al. showed that a combination of cytokeratin 5/6 (CK5/6), p63, p40 and MUC5AC are useful in differentiating cervical adenocarcinoma from cervical squamous cell carcinoma using immunohistochemistry ⁷

CK5/6

p63

p40

MUC5AC

Products for Cervical Cancer Research

References:

1. Pal A, Kundu R. Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy. Front Microbiol. 2020 Jan 21;10:3116.
2. Wang Z, Jiang C, Pang L, Jia W, Wang C, Gao X, Zhang X, Dang H, Ren Y. ANXA2 is a potential marker for the diagnosis of human cervical cancer. Biomark Med. 2021 Jan;15(1):57-67.
3. Liu X, Song J, Zhang Y, Wang H, Sun H, Feng X, Hou M, Chen G, Tang Q, Ji M. ASF1B promotes cervical cancer progression through stabilization of CDK9. Cell Death Dis. 2020 Aug 26;11(8):705
4. Keeratichamroen S, Subhasitanont P, Chokchaichamnankit D, Weeraphan C, Saharat K, Sritana N, Kantathavorn N, Wiriyaukaradecha K, Sricharunrat T, Paricharttanakul NM, Auewarakul C, Svasti J, Srisomsap C. Identification of potential cervical cancer serum biomarkers in Thai patients. Oncol Lett. 2020 Jun;19(6):3815-3826.
5. Burk R. et al. The Cancer Genome Atlas Research Network., Nature 543, 378–384 (2017).
6. Li H, Jing X, Yu J, et al. A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix. Diagn Pathol. 2020;15(1):104
7. Ma Y et al. Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis. Thorac Cancer. 2015;6(3):288–95.