CARD9 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC, WB
Recommend Dilution	CARD9 antibody can be used for detection of CARD9 by Western blot at 2.5 µg/mL. A band at approximately 59 kDa can be detected. Antibody can also be used for immunocytochemistry starting at 10 µg/mL. Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	CARD9 antibody was raised against a synthetic peptide corresponding to amino acids 521 to 536 of human CARD9 The sequence is different from that of rat origin by two amino acids.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CARD9 Antibody is DEAE purified.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase recruitment domain family member 9
Database Link	AF311287 Entrez Gene 64170 Human UniProt ID Q9H257
Background	Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of BCL-10 (1). CARD9 associates with BCL-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-kappaB. CARD9 is an upstream activator of BCL-10 and NF-kappaB signaling.
Synonyms	CANDF2; hCARD9
Reference Data

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