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Beclin 1 (BECN1) Rabbit Polyclonal Antibody
CAT＃: TA321595S
Anti-BECN1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Mouse brain tissue, 293T cell lysates IHC: 50-100 Positive control: Human prostate cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 50-65 amino acids of Human beclin 1, autophagy related |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | beclin 1 |
| Database Link | |
| Background | Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is also known as autophagy-related gene (Atg) 6. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K); also named Vps34; which are participates in the regulation of autophagy and has an important role in development; tumorigenesis; and neurodegeneration. Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon; or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. |
| Synonyms | ATG6; beclin1; VPS30 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Regulation of autophagy |
Documents
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