LAT Mouse Monoclonal Antibody [Clone ID: 11B.12]

Specifications

Product Data
Clone Name	11B.12
Applications	WB
Recommend Dilution	WB, IP
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	GST fusion protein corresponding to residues 31-233 of human LAT, cytoplasmic domain
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28 kD but expected at 36-38 kD
Gene Name	linker for activation of T-cells
Database Link	NP_001014987 Entrez Gene 16797 MouseEntrez Gene 27040 Human UniProt ID O43561
Background	LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcεRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation.
Synonyms	LAT1; pp36
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

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