RIP (RIPK1) (NM_003804) Human Tagged ORF Clone
CAT#: RC216024
- TrueORF®
RIPK1 (Myc-DDK-tagged)-Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)
ORF Plasmid: tGFP
"NM_003804" in other vectors (7)
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CNY 4,912.00
CNY 5,800.00
Cited in 8 publications. |
CNY 300.00
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | AIEFL; IMD57; RIP; RIP-1; RIP1 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC216024 representing NM_003804
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCAACCAGACATGTCCTTGAATGTCATTAAGATGAAATCCAGTGACTTCCTGGAGAGTGCAGAACTGG ACAGCGGAGGCTTCGGGAAGGTGTCTCTGTGTTTCCACAGAACCCAGGGACTCATGATCATGAAAACAGT GTACAAGGGGCCCAACTGCATTGAGCACAACGAGGCCCTCTTGGAGGAGGCGAAGATGATGAACAGACTG AGACACAGCCGGGTGGTGAAGCTCCTGGGCGTCATCATAGAGGAAGGGAAGTACTCCCTGGTGATGGAGT ACATGGAGAAGGGCAACCTGATGCACGTGCTGAAAGCCGAGATGAGTACTCCGCTTTCTGTAAAAGGAAG GATAATTTTGGAAATCATTGAAGGAATGTGCTACTTACATGGAAAAGGCGTGATACACAAGGACCTGAAG CCTGAAAATATCCTTGTTGATAATGACTTCCACATTAAGATCGCAGACCTCGGCCTTGCCTCCTTTAAGA TGTGGAGCAAACTGAATAATGAAGAGCACAATGAGCTGAGGGAAGTGGACGGCACCGCTAAGAAGAATGG CGGCACCCTCTACTACATGGCGCCCGAGCACCTGAATGACGTCAACGCAAAGCCCACAGAGAAGTCGGAT GTGTACAGCTTTGCTGTAGTACTCTGGGCGATATTTGCAAATAAGGAGCCATATGAAAATGCTATCTGTG AGCAGCAGTTGATAATGTGCATAAAATCTGGGAACAGGCCAGATGTGGATGACATCACTGAGTACTGCCC AAGAGAAATTATCAGTCTCATGAAGCTCTGCTGGGAAGCGAATCCGGAAGCTCGGCCGACATTTCCTGGC ATTGAAGAAAAATTTAGGCCTTTTTATTTAAGTCAATTAGAAGAAAGTGTAGAAGAGGACGTGAAGAGTT TAAAGAAAGAGTATTCAAACGAAAATGCAGTTGTGAAGAGAATGCAGTCTCTTCAACTTGATTGTGTGGC AGTACCTTCAAGCCGGTCAAATTCAGCCACAGAACAGCCTGGTTCACTGCACAGTTCCCAGGGACTTGGG ATGGGTCCTGTGGAGGAGTCCTGGTTTGCTCCTTCCCTGGAGCACCCACAAGAAGAGAATGAGCCCAGCC TGCAGAGTAAACTCCAAGACGAAGCCAACTACCATCTTTATGGCAGCCGCATGGACAGGCAGACGAAACA GCAGCCCAGACAGAATGTGGCTTACAACAGAGAGGAGGAAAGGAGACGCAGGGTCTCCCATGACCCTTTT GCACAGCAAAGACCTTACGAGAATTTTCAGAATACAGAGGGAAAAGGCACTGCTTATTCCAGTGCAGCCA GTCATGGTAATGCAGTGCACCAGCCCTCAGGGCTCACCAGCCAACCTCAAGTACTGTATCAGAACAATGG ATTATATAGCTCACATGGCTTTGGAACAAGACCACTGGATCCAGGAACAGCAGGTCCCAGAGTTTGGTAC AGGCCAATTCCAAGTCATATGCCTAGTCTGCATAATATCCCAGTGCCTGAGACCAACTATCTAGGAAATA CACCCACCATGCCATTCAGCTCCTTGCCACCAACAGATGAATCTATAAAATATACCATATACAATAGTAC TGGCATTCAGATTGGAGCCTACAATTATATGGAGATTGGTGGGACGAGTTCATCACTACTAGACAGCACA AATACGAACTTCAAAGAAGAGCCAGCTGCTAAGTACCAAGCTATCTTTGATAATACCACTAGTCTGACGG ATAAACACCTGGACCCAATCAGGGAAAATCTGGGAAAGCACTGGAAAAACTGTGCCCGTAAACTGGGCTT CACACAGTCTCAGATTGATGAAATTGACCATGACTATGAGCGAGATGGACTGAAAGAAAAGGTTTACCAG ATGCTCCAAAAGTGGGTGATGAGGGAAGGCATAAAGGGAGCCACGGTGGGGAAGCTGGCCCAGGCGCTCC ACCAGTGTTCCAGGATCGACCTTCTGAGCAGCTTGATTTACGTCAGCCAGAAC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC216024 representing NM_003804
Red=Cloning site Green=Tags(s) MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRL RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLK PENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSD VYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPG IEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLG MGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWY RPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDST NTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQ MLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Chromatograms |
CHROMATOGRAMS
Sequencher program is needed, download here. |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_003804 |
ORF Size | 2013 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_003804.6 |
RefSeq Size | 3864 bp |
RefSeq ORF | 2016 bp |
Locus ID | 8737 |
UniProt ID | Q13546 |
Domains | DEATH, pkinase, TyrKc, S_TKc |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway |
MW | 75.8 kDa |
Gene Summary | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017] |
Citations (8)
The use of this cDNA Clones has been cited in the following citations: |
---|
Intestinal vitamin D receptor signaling ameliorates dextran sulfate sodium-induced colitis by suppressing necroptosis of intestinal epithelial cells
,Shi, Y;Cui, X;Sun, Y;Zhao, Q;Liu, T;,
FASEB J.
,PubMed ID 32779265
[RIP]
|
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
,Lalaoui, N;Boyden, SE;Oda, H;Wood, GM;Stone, DL;Chau, D;Liu, L;Stoffels, M;Kratina, T;Lawlor, KE;Zaal, KJM;Hoffmann, PM;Etemadi, N;Shield-Artin, K;Biben, C;Tsai, WL;Blake, MD;Kuehn, HS;Yang, D;Anderton, H;Silke, N;Wachsmuth, L;Zheng, L;Moura, NS;Beck, DB;Gutierrez-Cruz, G;Ombrello, AK;Pinto-Patarroyo, GP;Kueh, AJ;Herold, MJ;Hall, C;Wang, H;Chae, JJ;Dmitrieva, NI;McKenzie, M;Light, A;Barham, BK;Jones, A;Romeo, TM;Zhou, Q;Aksentijevich, I;Mullikin, JC;Gross, AJ;Shum, AK;Hawkins, ED;Masters, SL;Lenardo, MJ;Boehm, M;Rosenzweig, SD;Pasparakis, M;Voss, AK;Gadina, M;Kastner, DL;Silke, J;,
Nature
,PubMed ID 31827281
[RIP]
|
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1
,Tao, P;Sun, J;Wu, Z;Wang, S;Wang, J;Li, W;Pan, H;Bai, R;Zhang, J;Wang, Y;Lee, PY;Ying, W;Zhou, Q;Hou, J;Wang, W;Sun, B;Yang, M;Liu, D;Fang, R;Han, H;Yang, Z;Huang, X;Li, H;Deuitch, N;Zhang, Y;Dissanayake, D;Haude, K;McWalter, K;Roadhouse, C;MacKenzie, JJ;Laxer, RM;Aksentijevich, I;Yu, X;Wang, X;Yuan, J;Zhou, Q;,
Nature
,PubMed ID 31827280
[RIP]
|
ACTN4 regulates the stability of RIPK1 in melanoma
,Zhang, YY;Tabataba, H;Liu, XY;Wang, JY;Yan, XG;Farrelly, M;Jiang, CC;Guo, ST;Liu, T;Kao, HY;Thorne, RF;Zhang, XD;Jin, L;,
Oncogene
,PubMed ID 29706658
[RIP]
|
RIP1 upregulation promoted tumor progression by activating AKT/Bcl-2/BAX signaling and predicted poor postsurgical prognosis in HCC
,Wang, C;Yao, B;Xu, M;Zheng, X;,
Tumour Biol.
,PubMed ID 27699664
[RIP]
|
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
,Zhou, Q;Wang, H;Schwartz, DM;Stoffels, M;Park, YH;Zhang, Y;Yang, D;Demirkaya, E;Takeuchi, M;Tsai, WL;Lyons, JJ;Yu, X;Ouyang, C;Chen, C;Chin, DT;Zaal, K;Chandrasekharappa, SC;P Hanson, E;Yu, Z;Mullikin, JC;Hasni, SA;Wertz, IE;Ombrello, AK;Stone, DL;Hoffmann, P;Jones, A;Barham, BK;Leavis, HL;van Royen-Kerkof, A;Sibley, C;Batu, ED;Gül, A;Siegel, RM;Boehm, M;Milner, JD;Ozen, S;Gadina, M;Chae, J;Laxer, RM;Kastner, DL;Aksentijevich, I;,
Nat. Genet.
,PubMed ID 26642243
[RIP]
|
RIP1 Kinase Is an Oncogenic Driver in Melanoma
,Liu, XY;Lai, F;Yan, XG;Jiang, CC;Guo, ST;Wang, CY;Croft, A;Tseng, HY;Wilmott, JS;Scolyer, RA;Jin, L;Zhang, XD;,
Cancer Res.
,PubMed ID 25724678
[RIP]
|
Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses
,Xiaobo Lei, Xia Xiao, Qinghua Xue, Qi Jin, Bin He, and Jianwei Wang,
J. Virol., Feb 2013; 87: 1690 - 1698.
[RIP]
|
Documents
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC216024L1 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), Myc-DDK-tagged |
CNY 7,312.00 |
|
RC216024L2 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mGFP tagged |
CNY 7,700.00 |
|
RC216024L3 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), Myc-DDK-tagged |
CNY 7,312.00 |
|
RC216024L4 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mGFP tagged |
CNY 7,312.00 |
|
RG216024 | RIPK1 (tGFP-tagged) - Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) |
CNY 6,370.00 |
|
SC108466 | RIPK1 (untagged)-Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) |
CNY 4,920.00 |
|
SC323466 | RIPK1 (untagged)-Kinase deficient mutant (K45M) of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) |
CNY 4,920.00 |