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RIP (RIPK1) (NM_003804) Human Untagged Clone
CAT＃: SC108466
RIPK1 (untagged)-Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)
CNY 4,920.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AIEFL; IMD57; RIP; RIP-1; RIP1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_003804 edited
ATGCAACCAGACATGTCCTTGAATGTCATTAAGATGAAATCCAGTGACTTCCTGGAGAGT GCAGAACTGGACAGCGGAGGCTTCGGGAAGGTGTCTCTGTGTTTCCACAGAACCCAGGGA CTCATGATCATGAAAACAGTGTACAAGGGGCCCAACTGCATTGAGCACAACGAGGCCCTC TTGGAGGAGGCGAAGATGATGAACAGACTGAGACACAGCCGGGTGGTGAAGCTCCTGGGC GTCATCATAGAGGAAGGGAAGTACTCCCTGGTGATGGAGTACATGGAGAAGGGCAACCTG ATGCACGTGCTGAAAGCCGAGATGAGTACTCCGCTTTCTGTAAAAGGAAGGATAATTTTG GAAATCATTGAAGGAATGTGCTACTTACATGGAAAAGGCGTGATACACAAGGACCTGAAG CCTGAAAATATCCTTGTTGATAATGACTTCCACATTAAGATCGCAGACCTCGGCCTTGCC TCCTTTAAGATGTGGAGCAAACTGAATAATGAAGAGCACAATGAGCTGAGGGAAGTGGAC GGCACCGCTAAGAAGAATGGCGGCACCCTCTACTACATGGCGCCCGAGCACCTGAATGAC GTCAACGCAAAGCCCACAGAGAAGTCGGATGTGTACAGCTTTGCTGTAGTACTCTGGGCG ATATTTGCAAATAAGGAGCCATATGAAAATGCTATCTGTGAGCAGCAGTTGATAATGTGC ATAAAATCTGGGAACAGGCCAGATGTGGATGACATCACTGAGTACTGCCCAAGAGAAATT ATCAGTCTCATGAAGCTCTGCTGGGAAGCGAATCCGGAAGCTCGGCCGACATTTCCTGGC ATTGAAGAAAAATTTAGGCCTTTTTATTTAAGTCAATTAGAAGAAAGTGTAGAAGAGGAC GTGAAGAGTTTAAAGAAAGAGTATTCAAACGAAAATGCAGTTGTGAAGAGAATGCAGTCT CTTCAACTTGATTGTGTGGCAGTACCTTCAAGCCGGTCAAATTCAGCCACAGAACAGCCT GGTTCACTGCACAGTTCCCAGGGACTTGGGATGGGTCCTGTGGAGGAGTCCTGGTTTGCT CCTTCCCTGGAGCACCCACAAGAAGAGAATGAGCCCAGCCTGCAGAGTAAACTCCAAGAC GAAGCCAACTACCATCTTTATGGCAGCCGCATGGACAGGCAGACGAAACAGCAGCCCAGA CAGAATGTGGCTTACAACAGAGAGGAGGAAAGGAGACGCAGGGTCTCCCATGACCCTTTT GCACAGCAAAGACCTTACGAGAATTTTCAGAATACAGAGGGAAAAGGCACTGCTTATTCC AGTGCAGCCAGTCATGGTAATGCAGTGCACCAGCCCTCAGGGCTCACCAGCCAACCTCAA GTACTGTATCAGAACAATGGATTATATAGCTCACATGGCTTTGGAACAAGACCACTGGAT CCAGGAACAGCAGGTCCCAGAGTTTGGTACAGGCCAATTCCAAGTCATATGCCTAGTCTG CATAATATCCCAGTGCCTGAGACCAACTATCTAGGAAATACACCCACCATGCCATTCAGC TCCTTGCCACCAACAGATGAATCTATAAAATATACCATATACAATAGTACTGGCATTCAG ATTGGAGCCTACAATTATATGGAGATTGGTGGGACGAGTTCATCACTACTAGACAGCACA AATACGAACTTCAAAGAAGAGCCAGCTGCTAAGTACCAAGCTATCTTTGATAATACCACT AGTCTGACGGATAAACACCTGGACCCAATCAGGGAAAATCTGGGAAAGCACTGGAAAAAC TGTGCCCGTAAACTGGGCTTCACACAGTCTCAGATTGATGAAATTGACCATGACTATGAG CGAGATGGACTGAAAGAAAAGGTTTACCAGATGCTCCAAAAGTGGGTGATGAGGGAAGGC ATAAAGGGAGCCACGGTGGGGAAGCTGGCCCAGGCGCTCCACCAGTGTTCCAGGATCGAC CTTCTGAGCAGCTTGATTTACGTCAGCCAGAACTAA >OriGene 5' read for NM_003804 unedited
CAGTATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGGCGTTCTT GAGCTTCAGAATGCAACCAGACTGTCCTTGAATGTCATTAAGATGAAATCCAGTGACTTC CTGGAGAGTGCAGAACTGGACAGCGGAGGCTTCGGGAAGGTGTCTCTGTGTTTCCACAGA ACCCAGGGACTCATGATCATGAAAACAGTGTACAAGGGGCCCAACTGCATTGAGCACAAC GAGGCCCTCTTGGAGGAGGCGAAGATGATGAACAGACTGAGACACAGCCGGGTGGTGAAG CTCCTGGGCGTCATCATAGAGGAAGGGAAGTACTCCCTGGTGATGGAGTACATGGAGAAG GGCAACCTGATGCACGTGCTGAAAGCCGAGATGAGTACTCCGCTTTCTGTAAAAGGAAGG ATAATTTTGGAAATCATTGAAGGAATGTGCTACTTACATGGAAAAGGCGTGATACACAAG GACCTGAAGCCTGAAAATATCCTTGTTGATAATGACTTCCACATTAAGATCGCAGACCTC GGCCTTGCCTCCTTTAAGATGTGGAGCAAACTGAATAATGAAGAGCACAATGAGCTGAGG GAAGTGGACGGCACCGCTAAGAAGAATGGCGGCACCCTCTACTACATGGCGCCCGAGCAC CTGAATGACGTCAACGCAAAGCCCACAGAGAAGTCGGATGTGTACAGCTTTGCTGTAGTA CTCTGGGCGATATTTGCAAATAAGGAGCCCATATGAAATGCTATCTGTGAGCAGCAGTTG ATAATGTGCATAAAATCTGGGAACAGGCCAGATGTGGATGACATCACTGAGTACTGCCCA AGAGA >OriGene 3' read for NM_003804 unedited
TCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTGGGGGATAAATTTTTATTTTAAAAA GTGTTAAAAAATGCCTTGCCCTCTTGCCTTTGAACATTAATTATTCAACCTCTTTGGAAT CTAAGAGATTTGATAACACCATTTGGATGGTGGTACAAGGAGCAAACAGAACTCACCCAG GCCCCTCCAGCAAAGCCTGGAGCCTCCCTCCATTCTCCCTTTTGGGCTGTAGGAGCCAAG GCTGCGTGGTGGCCAAGTAGTAACCGGACAGGTGCAGACAGGAGAGCCGAGGCTCATTAC TTTACAGCAGTGCTCTTCTCAACCGGGGCAATTTTCCCCTTTCCTTGGACCATTTGACAA TGTTTAGAGACTATTGTCACAACTGGGGCGGGGGGCTGGGGAGAACAGTGCCCCTGGCAT CTAGTAGGTGGGGGCAGGGATGCTACTAAACATCCTACAAGGAACAGGACAGTCCCCACA ACAGAATTACCCCAGCCCGAGATGCCGACAGTGGCAAGGCTGAGACAGCCTGCTCTGCAC CCCATTTCAGGGGTGTGTATGTGTCTGCTAGAGTTGAGGGGATTTACAATCAGAATCAAC CACACTGTTATCAGCCCAAGAACCAGAATCTGTCCGACAGCCAGATTGCCATTACACACC CTTTTTGGCCTCCCTCTGGGGAGAGCTAGCACAAAGCCTTCCTTTGTCCGTTTACAAAAT GCCAGTGACACTGAGCGGGCTACCCAGCTTAAGCTTTTATATTAGTCTTTAATCCCCCCC AAGTTTAAGTGGCCTTTGAAGGCTGGTGCTAAAGCCCAATACCCACTTAGAGCTGCCTTT TTACTTTGTCCCCAGAAAAATTGAAAATCTTTCAGTCCCCGATTAACCGAGGAACCCTTA ACAGTTAACCCTTGGGTTCTGGCTACCCAAGTAAAAAAAAATTTCTGTTCTTCCAAGCCC TACGCTGGGAGGCCAAATGCCGAAAACTTTAAGTATCAGATTTTGTGACCACGTAAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003804 |
| Insert Size | 3900 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003804.3, NP_003795.2 |
| RefSeq Size | 3864 bp |
| RefSeq ORF | 2016 bp |
| Locus ID | 8737 |
| UniProt ID | Q13546 |
| Domains | DEATH, pkinase, TyrKc, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway |
| Gene Summary | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The Tyrosine Kinase BMX Is an Essential Mediator of Inflammatory Arthritis in a Kinase-Independent Manner
,Marie Gottar-Guillier, Francis Dodeller, Dieter Huesken, Vadim Iourgenko, Craig Mickanin, Mark Labow, Samuel Gaveriaux, Bernd Kinzel, Matthias Mueller, Kari Alitalo, Amanda Littlewood-Evans, and Bruno Cenni,
J. Immunol., May 2011; 186: 6014 - 6023
[RIPK1]
|
|
The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways
,Francis Dodeller, Marie Gottar, Dieter Huesken, Vadim Iourgenko, and Bruno Cenni,
J. Biol. Chem., Aug 2008; 283: 21487 - 21494
[RIPK1]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC216024 | RIPK1 (Myc-DDK-tagged)-Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) |
CNY 4,912.00 |
|
| RC216024L1 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), Myc-DDK-tagged |
CNY 7,312.00 |
|
| RC216024L2 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mGFP tagged |
CNY 7,700.00 |
|
| RC216024L3 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), Myc-DDK-tagged |
CNY 7,312.00 |
|
| RC216024L4 | Lenti ORF clone of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mGFP tagged |
CNY 7,312.00 |
|
| RG216024 | RIPK1 (tGFP-tagged) - Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) |
CNY 6,512.00 |
|
| SC323466 | RIPK1 (untagged)-Kinase deficient mutant (K45M) of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) |
CNY 4,920.00 |
