ZNF568 (NM_001204838) Human Tagged ORF Clone

Specifications

Product Data
Type	Human Tagged ORF Clone
Tag	Myc-DDK
Synonyms	ZFP568
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >RC234617 representing NM_001204838 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGACATCTCAATCTTCAGTGATCAGCAATAGCTGTGTGACAATGGAGCGTTTGAGCCACATGATGGAAA GGAAAGCTTGGTGTTCTCAAGAGTCTGCCCTTTCCGAGGAAGAAGAGGATACAACCAGGCCTCTTGAAAC AGTGACATTTAAGGATGTGGCTGTTGACCTTACCCAGGAGGAGTGGGAGCAAATGAAACCTGCTCAAAGA AACTTGTATCGAGATGTGATGCTGGAGAACTACAGCAACCTAGTCACAGTGGGCTGTCAAGTCACCAAAC CGGATGTGATATTCAAGTTGGAGCAAGAAGAGGAGCCCTGGGTGATGGAGGAAGAAATGTTTGGGAGGCA CTGTCCAGAACCCAGAAGAGGAGAGAACTGCTGTGCGTCTGAAGTGATGGCGGAGGGCTTGAAGTTCAAA GATGTGGTCATTTACTTCTCTCAAAAGGAGTGGGAATGCTTGCACTCTGCTCAGAAGGATTTGTACCGAG ATGTAATGTTGGAAAATTACGGCAACCTGGTCTTACTGGGGCTTTCTGATACTAAGCCAAATGTGATCTC CTTATTGGAGCAGAAGAAAGAGCCCTGGATGGTTAAGAGGAAGGAGACAAAAGAATGGTGTCCAGATTGG GAGTTTGGAAGAGAAACCAAGAATTTATCTCCAAAGGAAAACATTTATGAAATTAGATCACCACAACAGG AGAAGGCCAGAGTTATCAGAGAAATCAGATGCCAGGTGGAGAGACAACAGGGTCATCAGGAGGGACATTT CAGACCAGCTGTAATACCATTTACTTCCATGCAGTGCACAGCCCATAGAGAATATCAGTGGCTTCATACT GGAGAGAAATCCTGTGAATGCAGGAAATGTAAGAATGCTTTTAGGTACCAGTCATGTCCTATTCAACATG AAATAATTCATAATAAGGAAAAAGAACCTGAATGTGGAGAATGTAGGAAAATCTTTAATAGTGGATCAGA CTTGATTAAGCATCAGACGCTTCATGAAAGCAAAAAACATAGTGAAAATAACAAATGTGCCTTTAATCAT GATTCTGGAATTACTCAACCTCAGAGCATTAATACTGGAGAGAAACCTCATAAATGTAAGGAATGTGGGA AAGCCTTTCGTTCCAGCTCACAAATTAGTCAGCATCAGAGGATGCATCTTGGTGAGAAACCCTATAAGTG TAGGGAGTGTGGGAAAGCCTTTCCATCCACTGCACAGCTTAATCTACATCAGAGGATCCATACTGATGAG AAATACTATGAAAGTAAGGCGTGTGGGAAGGCCTTTACCCGTCCCTCACACCTTTTTCGACATCAAAGAA TCCATACGGGTGAGAAACCCCATAAATGTAAGGAATGTGGAAAGGCTTTTCGTTATGACACACAGCTGAG CCTTCATCAGATAATCCATACTGGTGAAAGACGCTATGAATGCAGGGAGTGTGGAAAGGTGTACAGTTGT GCCTCACAGCTGAGTCTACATCAAAGAATTCATACTGGTGAGAAACCCCATGAATGTAAGGAATGTGGGA AAGCCTTTATCTCTGATTCACATCTTATTCGACATCAGAGTGTCCATACTGGGGAGAAACCCTGTAAGTG TAAGGAATGTGGGAAGTCCTTTCGTCGTGGCTCAGAACTTACCCGACATCAGAGAGCTCATACTGGTGAA AAACCCTATGAGTGTAAGGAATGTGAAAAGGCCTTTACTTGTAGCACAGAACTTGTTCGACATCAAAAAG TTCACACTGGGGAGAGACCCCATAAGTGTAAGGAATGTGGGAAGGCTTTCATTCGAAGGTCAGAACTCAC ACATCATGAGAGAAGTCACACTGGTGAGAAACCCTACGAGTGTAAGGAGTGTGGGAAGCCCTTTGGTGGT GGCTCAGAACTTAGT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >RC234617 representing NM_001204838 Red=Cloning site Green=Tags(s) MTSQSSVISNSCVTMERLSHMMERKAWCSQESALSEEEEDTTRPLETVTFKDVAVDLTQEEWEQMKPAQR NLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQEEEPWVMEEEMFGRHCPEPRRGENCCASEVMAEGLKFK DVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWMVKRKETKEWCPDW EFGRETKNLSPKENIYEIRSPQQEKARVIREIRCQVERQQGHQEGHFRPAVIPFTSMQCTAHREYQWLHT GEKSCECRKCKNAFRYQSCPIQHEIIHNKEKEPECGECRKIFNSGSDLIKHQTLHESKKHSENNKCAFNH DSGITQPQSINTGEKPHKCKECGKAFRSSSQISQHQRMHLGEKPYKCRECGKAFPSTAQLNLHQRIHTDE KYYESKACGKAFTRPSHLFRHQRIHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGERRYECRECGKVYSC ASQLSLHQRIHTGEKPHECKECGKAFISDSHLIRHQSVHTGEKPCKCKECGKSFRRGSELTRHQRAHTGE KPYECKECEKAFTCSTELVRHQKVHTGERPHKCKECGKAFIRRSELTHHERSHTGEKPYECKECGKPFGG GSELS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_001204838
ORF Size	1905 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001204838.1, NP_001191767.1
RefSeq Size	2759 bp
RefSeq ORF	1908 bp
Locus ID	374900
UniProt ID	Q3ZCX4
Protein Families	Transcription Factors
MW	74.4 kDa
Gene Summary	Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.[UniProtKB/Swiss-Prot Function]

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