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Cyp46a1 (NM_010010) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208027L3V
- LentiORF®
-
Lenti ORF particles, Cyp46a1 (Myc-DDK-tagged) - Mouse cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), 200ul, >10^7 TU/mL
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CNY 9,500.00
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Specifications
| Product Data | |
| Product Name | Cyp46a1 (NM_010010) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Cyp46 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_010010 |
| ORF Size | 1503 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208027).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010010.1, NP_034140.1 |
| RefSeq Size | 2146 bp |
| RefSeq ORF | 1503 bp |
| Locus ID | 13116 |
| Gene Summary | P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:16505352, PubMed:28190002). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (PubMed:16505352). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (By similarity). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (By similarity). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (By similarity).[UniProtKB/Swiss-Prot Function] |
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