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Grk5 (NM_018869) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209199L3V
- LentiORF®
-
Lenti ORF particles, Grk5 (Myc-DDK-tagged) - Mouse G protein-coupled receptor kinase 5 (Grk5), 200ul, >10^7 TU/mL
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CNY 10,545.00
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Specifications
| Product Data | |
| Product Name | Grk5 (NM_018869) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Gprk5 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_018869 |
| ORF Size | 1773 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209199).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_018869.3 |
| RefSeq Size | 3182 bp |
| RefSeq ORF | 1773 bp |
| Locus ID | 14773 |
| Gene Summary | Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).[UniProtKB/Swiss-Prot Function] |
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