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Kcnma1 (NM_010610) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226365L4V
- LentiORF®
-
Lenti ORF particles, Kcnma1 (GFP-tagged) - Mouse potassium large conductance calcium-activated channel, subfamily M, alpha member 1 (Kcnma1), 200ul, >10^7 TU/mL
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CNY 19,855.00
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Specifications
| Product Data | |
| Product Name | Kcnma1 (NM_010610) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5730414M22Rik; BKCa; MaxiK; mSlo; mSlo1; Slo; Slo1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_010610 |
| ORF Size | 3708 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226365).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010610.3, NP_034740.2 |
| RefSeq Size | 5051 bp |
| RefSeq ORF | 3711 bp |
| Locus ID | 16531 |
| Gene Summary | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).[UniProtKB/Swiss-Prot Function] |
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