EIF4EL3 (EIF4E2) (NM_004846) Human Mass Spec Standard

Specifications

Product Data
Description	EIF4E2 MS Standard C13 and N15-labeled recombinant protein (NP_004837)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC201391
Predicted MW	28.4 kDa
Protein Sequence	Sequence Link (showhide) >RC201391 protein sequence Red=Cloning site Green=Tags(s) MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPG RPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLR KGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNT IMEYKTHTDSIKMPGRLGPQRLLFQNLWKPRLNVP TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_004837
RefSeq Size	1078
RefSeq ORF	735
Synonyms	4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e
Locus ID	9470
Cytogenetics	2q37.1
Summary	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB/Swiss-Prot Function]
Protein Families	Transcription Factors
Protein Pathways	Insulin signaling pathway, mTOR signaling pathway

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