Pdcd1 (NM_008798) Mouse Tagged ORF Clone Lentiviral Particle

CAT＃: MR227347L2V

LentiORF^®

Lenti ORF particles, Pdcd1 (GFP-tagged) - Mouse programmed cell death 1 (Pdcd1), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP

Datasheet

SDS

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CNY 8,360.00

货期*

详询

规格

Cited in 1 publication.

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Specifications

Product Data
Product Name	Pdcd1 (NM_008798) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms	Ly101; PD-1; Pdc1
Vector	pLenti-C-mGFP
ACCN	NM_008798
ORF Size	867 bp
Sequence Data	ORF Nucleotide Sequence (showhide) The ORF insert of this clone is exactly the same as(MR227347).
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NM_008798.2, NP_032824.1
RefSeq Size	1972 bp
RefSeq ORF	867 bp
Locus ID	18566
Gene Summary	Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:10485649, PubMed:11698646, PubMed:11209085, PubMed:21300912). Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:11015443, PubMed:11224527, PubMed:22641383, PubMed:18287011, PubMed:18641123). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:22641383). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (PubMed:11698646, PubMed:22641383). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity).[UniProtKB/Swiss-Prot Function]

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

The use of this cDNA Clones has been cited in the following citations:
Blockade of Tumor-Expressed PD-1 Promotes Lung Cancer Growth ,Du, S;McCall, N;Park, K;Guan, Q;Fontina, P;Ertel, A;Zhan, T;Dicker, AP;Lu, B;, OncoImmunology [Pdcd1]

Documents

Product Manuals
TrueORFs: Open Reading Frame Clones - 10 ug in PrecisionShuttle Vector System pLenti-ORF destination vector Transfection - TurboFectin 8.0 Transfection Reagent Plasmid Preparation - PowerPrep Plasmid Purification Kits
FAQs
TrueORF Clones/PrecisionShuttle Organelle Marker Transfection Reagent
SDS
Lenti SDS

Resources

cDNA 克隆相关资源
Video Tutorial: Clone Selection Guide Product Video: What is TrueORF GOLD and why it is the most popular type of clone Video Tutorial: How to make Lentivirus particles Video Tutorial: Is the Lentivirus Safe Product Brochure: cDNA clones $98 Clones. Download the List of 15,000 Protocol: Lentivirus packaging

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