Pdcd1 Mouse Monoclonal Antibody [Clone ID: 7A11B1]

Specifications

Product Data
Clone Name	7A11B1
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	A ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.
Formulation	PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	programmed cell death 1
Database Link	NP_005009 Entrez Gene 18566 Mouse UniProt ID Q02242
Background	PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Synonyms	CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.