Bovine Corona Virus E2 protein Mouse Monoclonal Antibody [Clone ID: 5A4]
CAT#: AM00683PU-N
Bovine Corona Virus E2 protein mouse monoclonal antibody, clone 5A4, Purified
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CNY 8,175.00
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Specifications
Product Data | |
Clone Name | 5A4 |
Applications | ELISA |
Recommend Dilution | ELISA. HIT (hemagglutination inhibition titer). |
Reactivity | Bovine Coronavirus |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Bovine corona virus. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice. |
Specificity | Recognizes bovine corona virus surface antigen (peplomer). |
Formulation | PBS, pH 7.4 containing 0.09% Sodium azide State: Purified State: Liquid purified IgG |
Concentration | lot specific |
Purification | >95% pure (SDS-PAGE). Protein G chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! |
Database Link | |
Background | Bovine Corona Virus Spike glycoprotein is cleaved into S1 and S2 Spike proteins. The precursor is processed into S1 and S2 by host cell furin or furin-like protease to yield the mature S1 and S2 proteins. The cleavage site between S1 and S2 requires the optimal sequence [KR]-X-[KR]-R. S1 attaches the virion to the cell membrane by binding to 9-O-acetylated sialic acid containing proteins, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. |
Synonyms | Spike glycoprotein, S glycoprotein, Peplomer protein, E2 protein |
Note | Centrifuge before opening to ensure complete recovery of vial contents. |
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