Influenza A (Haemagglutinin H3) Mouse Monoclonal Antibody [Clone ID: B263M]

Specifications

Product Data
Clone Name	B263M
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot.
Reactivity	Influenza A Virus
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Influenza A/Shangdong/9/93 (strain H3N2). Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.
Specificity	This antibody reacts to Influenza A Virus Hemagglutinin H3. Reacts with Hemagglutinin of H3 serotype.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction (>90% pure by SDS-PAGE).
Concentration	lot specific
Purification	Protein A Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Background	Influenza A Hemagglutinin 3 binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. The extent of infection into host organism is determined by HA. Influenza viruses bud from the apical surface of polarized epithelial cells (e.g. bronchial epithelial cells) into lumen of lungs and are therefore usually pneumotropic. The reason is that HA is cleaved by tryptase clara which is restricted to lungs. However, HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs.
Synonyms	Influenza A Virus, Seasonal Flu
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.