Glucocorticoid Receptor (NR3C1) Mouse Monoclonal Antibody [Clone ID: 5E4]

Specifications

Product Data
Clone Name	5E4
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of neat-1/10 diluted antibody to label 106 cells. Membrane permeabilisation is required for this application.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	26 amino acid peptide corresponding to residues 150-176 on Human GCR linked to thyroglobulin
Specificity	This antibody recognises a glucocorticoid receptor, located in the cytoplasm of cells and associated with certain heat shock proteins.
Formulation	PBS, pH 7.4, containing Label: FITC State: Liquid purified IgG fraction Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	nuclear receptor subfamily 3 group C member 1
Database Link	Entrez Gene 2908 Human UniProt ID P04150
Background	Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocoticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain glucocorticoid receptor.
Synonyms	NR3C1, GR, GRL
Reference Data

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