Il17a Rat Monoclonal Antibody [Clone ID: TC11-18H10]

Specifications

Product Data
Clone Name	TC11-18H10
Applications	ELISA, FC, IHC, WB
Recommend Dilution	Western Blot. Flow Cytometry. ELISA: Can be used in a Sandwich ELISA with AM01281BT-N as a detection antibody. This Clone has been described to work in Immunohistochemistry on Paraffin Sections.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Specificity	This antibody recognizes Mouse Interleukin 17, a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family
Formulation	Borate buffered saline with no preservative or stabilizer State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody in aliquots at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 17A
Database Link	Entrez Gene 16171 Mouse UniProt ID Q62386
Background	IL17, also known as CTLA8, is a T cell derived hematopoietic cytokine. It was originally cloned from a T cell hybridoma produced by fusion of a mouse cytotoxic T cell clone and a rat T lymphoma. IL17 exhibits multiple biological activities on a variety of cells including: the induction of IL6, IL8 and GCSF production in fibroblasts; the enhancement of surface expression of ICAM 1 in fibroblasts; activation of NF kappaB and costimulation of T cell proliferation. IL17 is an approximately 16 kDa polypeptide of 136 amino acids. The precursor form of IL17 consists of 155 amino acids. To generate the mature IL17 (136 amino acids), the precursor cleaves a 19 amino acid signal peptide. Human IL17 shows approximately 62.5% amino acid homology to mouse IL17 and 58% amino acid homology to rat IL17.
Synonyms	IL-17A, IL17, IL-17, CTLA8, CTLA-8
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.