C1QA Mouse Monoclonal Antibody [Clone ID: 3R9/2]

Specifications

Product Data
Clone Name	3R9/2
Applications	ELISA, FC, IHC
Recommend Dilution	ELISA. Flow Cytometry. Immunohistochemistry on Frozen Sections: It has been reported that this antibody works very well on acetone-fixed, frozen renal biopsies at a dilution of 1/500-1/600. Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant). Recommended Positive Control: Kidney tissue from patients with streptococal glomerulonephritis.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Binds globular head domain of C1q, purified from human plasma.
Specificity	This antibody recognises human complement component 1, q subcomponent (C1q), a 156kDa secreted protein.
Formulation	Borate Buffered Saline, pH 8.4 containing 0.02% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement component 1, q subcomponent, A chain
Database Link	Entrez Gene 712 Human UniProt ID P02745
Background	C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.
Synonyms	Complement C1q, Complement 1q
Reference Data

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