C4BPA Mouse Monoclonal Antibody [Clone ID: 10-07]

Specifications

Product Data
Clone Name	10-07
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Heat induced antigen retrieval in pH 6.0 citrate buffer is recommended.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Native Human C4 binding protein.
Specificity	This antibody recognizes complement component 4 binding protein (C4bp).
Formulation	Borate buffered saline, pH 8.4 containing 0.02% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement component 4 binding protein alpha
Database Link	Entrez Gene 722 Human UniProt ID P04003
Background	There are three variants of C4bp, composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.
Synonyms	C4BPA, C4BP, Proline-rich protein, PRP
Reference Data
Protein Pathways	Complement and coagulation cascades

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