Macrophage Inflammatory Protein 3 beta (CCL19) Mouse Monoclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: In a sandwich ELISA (assuming 100 µl/well), a concentration of 2-3 µg/ml of this antibody will detect at least 0.2 ng/well of recombinant human MIP-3-beta when used with biotinylated antigen affinity purified anti-human MIP-3-beta as the detection antibody at a concentration of at least 0.5 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human MIP-3-beta
Specificity	This antibody detects MIP-3 beta.
Formulation	State: Azide Free State: Lyophilized IgG fraction
Reconstitution Method	Restore in sterile water to a concentration of 1 mg/ml.
Purification	Protein A chromatography
Conjugation	Unconjugated
Storage Condition	The lyophilized antibody is stable at room temperature for one month or at -20 °C for longer. Following reconstitution it is stable at 2 - 8 °C for six weeks. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine ligand 19
Database Link	Entrez Gene 6363 Human UniProt ID Q99731
Background	MIP3 chemokines are among many novel beta chemokines recently identified through bioinformatics in the Expressed Sequence Tag (EST) database. They are distantly related to other beta chemokines (20-30% aa sequence homology). MIP3 chemokines are useful probes for studying the biology of inflammation and cell migration. Their expression is strongly up-regulated by inflammatory signals and down-regulated by the anti-inflammatory cytokine IL10. MIP3 beta is also known as ELC (EBI1-1 ligand chemokine) and is constitutively expressed in various lymphoid tissues (thymus, lymph nodes, appendix and spleen). MIP3 beta is a chemoattractant for cultured human lymphocytes, dendritic cells, human T lymphoblastoid CEM NKR2 and hemopoietic progenitor cells. It may be involved in G Protein activation in human NK cells. MIP3 beta is a unique functional ligand for CCR7. The MIP3 beta gene has been mapped to chormosome 9p13.
Synonyms	C-C motif chemokine 19, CCL-19, ELC, MIP3B, MIP-3 beta, Small-inducible cytokine A19, SCYA19, Exodus-3
Reference Data

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