BNP (NPPB) (NT-proBNP 1-21) Mouse Monoclonal Antibody [Clone ID: 21-6-6]

Specifications

Product Data
Clone Name	21-6-6
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry Paraffin Sections: 1/25 (Ref.1).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic Human pro-BNP (aa 1-21) poly-Lysine conjugated
Specificity	This antibody detects Synthetic Human proBNP (aa 1-21), Human proBNP
Formulation	200 mM Sodium Citrat / Tris, 500 mM NaCl buffer pH 7.5 containing 0.02% Sodium Azide State: Purified State: Lyophilized purified Cell Culture Supernatant
Reconstitution Method	Restore in aqua bidest to 1 mg/ml
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Gene Name	natriuretic peptide B
Database Link	Entrez Gene 4879 Human UniProt ID P16860
Background	In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa "signal" peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
Synonyms	NPPB, Brain natriuretic peptide, BNP, proBNP
Note	LocusID 4879
Reference Data

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