SHIP (INPP5D) Mouse Monoclonal Antibody [Clone ID: SHIP-02]

CAT#: AM03031PU-N

SHIP (INPP5D) mouse monoclonal antibody, clone SHIP-02, Aff - Purified



Need it in bulk or conjugated?
Get a free quote

CNY 3,410.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name SHIP-02
Applications ELISA, WB
Recommend Dilution Western Blotting (Reducing conditions)
Positive control: RAMOS human cell line.
Sample preparation: Resuspend approx. 50 mil. cells in 1 ml cold Lysis buffer (1% laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl pH 8.2, 50 mM NaF including Protease inhibitor Cocktail). Incubate 60 min on ice. Centrifuge to remove cell debris. Mix lysate with reducing Laemmli SDS-PAGE sample buffer. Boil for 6 min.
ELISA.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.
Specificity The antibody SHIP-02 reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells. Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa.
Formulation PBS, pH 7.4 with 15 mM sodium azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration lot specific
Purification Protein A affinity chromatography.
Conjugation Unconjugated
Storage Condition Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name inositol polyphosphate-5-phosphatase D
Background SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.
Synonyms SHIP, SHIP1, SHIP-1, p150Ship, SIP-145
Reference Data
Protein Families Druggable Genome
Protein Pathways B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Insulin signaling pathway, Phosphatidylinositol signaling system
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...