CD24 Mouse Monoclonal Antibody [Clone ID: SN3]

Specifications

Product Data
Clone Name	SN3
Applications	FC, IHC
Recommend Dilution	Immunohistochemistry on frozen sections. Flow Cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Glycoproteins purified from human NALM-1 cell line
Specificity	This antibody recognises the CD24 cell surface antigen, a heavily glycosylated molecule of 35-45kD, expressed by granulocytes and B lymphocytes, and by some activated T cells and T cell malignancies.
Formulation	Phosphate buffered saline pH7.4 State: Low Endotoxin State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	CD24 molecule
Database Link	Entrez Gene 100133941 Human UniProt ID P25063
Background	CD24 (also known as heat stable antigen) is a phosphatidylinositol linked cell surface glycoprotein with a polypeptide core of 30 amino acids and high carbohydrate content. The apparent molecular mass of the two forms of CD24 purified from a mouse lymphoma cell line appear to be in the range of 40-60 and 23-30 kDa. CD24 is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+ CD8+ CD24+ thymocytes to either CD4+ CD8- CD24- or CD4- CD8+ CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. CD24 is also a positive marker of pancreatic cancer.
Synonyms	X62 heat stable antigen, HSA
Note	Endotoxin Level: <0.01EU/µg
Reference Data

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