SOS1 Mouse Monoclonal Antibody [Clone ID: SOS-1]

Specifications

Product Data
Clone Name	SOS-1
Applications	ELISA, IF, WB
Recommend Dilution	Western Blotting under reducing conditions (1 µg/ml): Positive control: HeLa human cervix carcinoma cell line. Immunocytochemistry. ELISA.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
Specificity	The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.
Formulation	PBS, pH 7.4 with 15 mM sodium azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration	lot specific
Purification	Protein A affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid freeze/thaw cycles.
Gene Name	SOS Ras/Rac guanine nucleotide exchange factor 1
Database Link	Entrez Gene 20662 MouseEntrez Gene 6654 Human UniProt ID Q07889
Background	The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.
Synonyms	SOS-1, Son of sevenless homolog 1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Acute myeloid leukemia, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway

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