CD95 (FAS) Mouse Monoclonal Antibody [Clone ID: LT95]

CAT#: AM03061PU-N

CD95 (FAS) mouse monoclonal antibody, clone LT95, Purified

Conjugation: Unconjugated APC FITC PE



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CNY 3,140.00


货期*
5周

规格
    • 100 ug

Cited in 1 publication.

Product images

Specifications

Product Data
Clone Name LT95
Applications FC, IHC
Recommend Dilution Flow Cytometry.
Immunohistochemistry on Paraffin Sections.
Positive tissue: tonsil.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen HUT-78 Human T cell lymphoma cell line.
Specificity The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells.
It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.
Formulation PBS, pH 7.4
State: Purified
State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE)
Preservative: 15 mM Sodium Azide
Concentration lot specific
Purification Protein-A Affinity Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name Fas cell surface death receptor
Background CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
Synonyms FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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