CD95 (FAS) Mouse Monoclonal Antibody [Clone ID: LT95]
CAT#: AM03061PU-N
CD95 (FAS) mouse monoclonal antibody, clone LT95, Purified
Need it in bulk or conjugated?
Get a free quote
CNY 3,140.00
货期*
5周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Clone Name | LT95 |
Applications | FC, IHC |
Recommend Dilution | Flow Cytometry. Immunohistochemistry on Paraffin Sections. Positive tissue: tonsil. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | HUT-78 Human T cell lymphoma cell line. |
Specificity | The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule. |
Formulation | PBS, pH 7.4 State: Purified State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide |
Concentration | lot specific |
Purification | Protein-A Affinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | Fas cell surface death receptor |
Database Link | |
Background | CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses. |
Synonyms | FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6 |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
---|
Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
,Drosopoulos KG, Roberts ML, Cermak L, Sasazuki T, Shirasawa S, Andera L, Pintzas A,
J. Biol. Chem.
,PubMed ID 15757891
[FAS]
|
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...