CD30 (TNFRSF8) Mouse Monoclonal Antibody [Clone ID: MEM-268]
CAT#: AM03094PU-N
CD30 (TNFRSF8) mouse monoclonal antibody, clone MEM-268, Purified
Need it in bulk or conjugated?
Get a free quote
CNY 3,280.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | MEM-268 |
Applications | FC, IHC |
Recommend Dilution | Flow Cytometry: 5 µg/ml. Immunohistochemistry on Paraffin Sections (5 μg/ml). Positive tissue: thymus. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line) |
Specificity | The antibody MEM-268 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells; it is also found in Burkitt's lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor). |
Formulation | Phosphate buffered saline (PBS), pH 7.4 containing 15 mM Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | tumor necrosis factor receptor superfamily member 8 |
Database Link | |
Background | CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. |
Synonyms | TNFRSF8, D1S166E, CD30L receptor, KI-1 antigen |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
其它TNFRSF8产品
Customer
Reviews
Loading...