DR5 (TNFRSF10B) Mouse Monoclonal Antibody [Clone ID: DR5-01-1]

Specifications

Product Data
Clone Name	DR5-01-1
Applications	FC
Recommend Dilution	Flow Cytometry: 5 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
Specificity	The antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L).
Formulation	PBS containing 15 mM Sodium Azide as preservative and 0.2% (w/v) high-grade BSA (Protease free) as stabilizer. Label: PE State: Liquid purified IgG fraction. Label: Conjugated with R-Phycoerythrin under optimum conditions
Concentration	lot specific
Purification	Size-Exclusion Chromatography.
Conjugation	PE
Storage Condition	Store the antibody undiluted in the dark at 2-8°C. DO NOT FREEZE! Avoid prolonged exposure to light.
Gene Name	tumor necrosis factor receptor superfamily member 10b
Database Link	Entrez Gene 8795 Human UniProt ID O14763
Background	TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Synonyms	TNFRSF10B, DR5, KILLER, TRICK2, ZTNFR9, Death receptor 5, TRAIL receptor 2, TRAIL-R2
Reference Data

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