PSMA (FOLH1) (44-750) Mouse Monoclonal Antibody [Clone ID: GCP-05]

Specifications

Product Data
Clone Name	GCP-05
Applications	FC, IF, IP
Recommend Dilution	Flow Cytometry: 6 µg/ml. Immunoprecipitation. Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Amino acids 44-750 of Human PSMA/GCPII
Specificity	The antibody recognizes extracellular domain of Glutamate Carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 kDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
Formulation	Phosphate buffered saline (PBS), pH~7.4 State: Purified State: Liquid purified IgG fraction (>95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	folate hydrolase (prostate-specific membrane antigen) 1
Database Link	Entrez Gene 2346 Human UniProt ID Q04609
Background	Glutamate Carboxypeptidase II (GCPII), also known as N-acetyl-a-linked acidic dipeptidase I (NAALADase I), folate hydrolase (FOLH1), and prostate-specific membrane antigen (PSMA), is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate, which is released from neurons in a calcium-dependent manner, to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic, GCPII contributes to pathological conditions regarding e.g. Alzheimer's disease, Huntington's disease, epilepsy, schizophrenia, stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-g-glutamate to folate and glutamate, enabling folate to be absorbed by gastrointestinal tract. GCPII, which is present in a number of tissues at low levels, is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM') than mRNA for membrane-bound GCPII, and this ratio is reversed upon malignant transformation.
Synonyms	Glutamate carboxypeptidase 2, Folate hydrolase 1, Prostate-specific membrane antigen, FOLH, NAALAD1, PSM, GCP2, NAALAdase
Reference Data

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