Clathrin heavy chain (CLTC) Mouse Monoclonal Antibody [Clone ID: BF-06]

Specifications

Product Data
Clone Name	BF-06
Applications	ELISA, FC, IF, IP, WB
Recommend Dilution	Flow Cytometry: 2-5 µg/ml. Positive control: Human blood leukocytes. Immunoprecipitation. Western Blotting. Immunocytochemistry. ELISA.
Reactivity	Bovine, Human, Mouse, Porcine, Rat
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody recognizes Clathrin heavy chain, an ubiquitously expressed 180 kDa protein involved in receptor-mediated endocytosis.
Formulation	Stabilising Tris buffered saline (TBS) with 15 mM Sodium Azide, approx. pH 8.0 State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Precipitation and Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2-8°C. Do not freeze.
Gene Name	clathrin heavy chain
Database Link	Entrez Gene 54241 RatEntrez Gene 67300 MouseEntrez Gene 1213 Human UniProt ID Q00610
Background	Clathrin is a submembrane protein that polymerizes into coat-like lattices, which results in membrane invagination. The basic oligomers are composed of three clathrin heavy chain (180 kDa) and three light chain (30 kDa) subunits and the process of polymerization is dynamically regulated by the light chains. Interaction of clathrin with the plasma membrane is mediated by adaptor proteins (AP1-4) specific for different cellular compartments. Another proteins, such as endophilin, epsin and amphiphysin are involved in membrane invagination and clathrin rearrangements. Finally, dynamin functions at the fission stage of clathrin-mediated endocytosis.
Synonyms	CLTC, CLH17, CLTCL2, KIAA0034, Membrane Vesicle Marker
Reference Data
Protein Pathways	Endocytosis, Huntington's disease, Lysosome

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