NAPSIN A (NAPSA) (N-term) Mouse Monoclonal Antibody [Clone ID: KCG1.1]

Specifications

Product Data
Clone Name	KCG1.1
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: Use at 1/50-1/100 dilution in an ABC method (30 minutes at room temperature). However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the end user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Lung Adenocarcinoma.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide from N terminus of Human Napsin A
Specificity	Napsin A and TTF-1 reactivities were determined immunohistochemically on formalin-fixed paraffin embedded cell blocks from 50 pleural effusion (5 mesotheliomas, 10 mesothelial proliferations, 12 pulmonary, and 23 nonpulmonary metastases). TTF-1 and Napsin A were positive in 8/12 and 10/12 pulmonary adenocarcinomas, respectively. The specificity of this antibody for primary lung adenocarcinoma is 47 out of 58 (81%), primary lesions were positive. This antibody may be a useful tool as a tumor marker for primary lung adenocarcinoma.
Formulation	State: Purified State: Liquid purified Ig fraction Preservative: < 0.1% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	napsin A aspartic peptidase
Database Link	Entrez Gene 9476 Human UniProt ID O96009
Background	Napsin is found in two isoforms, A and B, with highly homologous gene sequences. Napsin A has a molecular weight of 35.0 kDa and is also known as TA02. Napsin A is an aspartic proteinase which is expressed in the lung and involved in processing surfactant protein B (SP-B). It is also expressed in the kidney.
Synonyms	NAPSA, NAP1, Napsin-1,Aspartyl protease 4, TA01/TA02
Note	Cellular Localization: Cytoplasmic
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.