SMC2 Mouse Monoclonal Antibody [Clone ID: E1M]

Specifications

Product Data
Clone Name	E1M
Applications	WB
Recommend Dilution	Western Blot: 1-5 µg/ml. Positive Control/Tissue Expression: HeLa cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant protein corresponding to amino acids 523-768 of Human CAP-E and Mouse myeloma cells.
Specificity	Recognizes SMC2/CAPE.
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C.
Gene Name	structural maintenance of chromosomes 2
Database Link	Entrez Gene 10592 Human UniProt ID O95347
Background	CAP-E and CAP-C (Chromosome Associated Protein-E & C) are also SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation to achieve proper segregation of genetic information during subsequent cell division. hCAP-C/hCAP-E is a component of a multiprotein complex called condensin that interacts with phosphorylation of Histone H3 resulting in the mitotic chromosome condensation. The distribution patterns of the two heterodimeric complexes in interphase nucleus indicate independent behaviour of the two complexes during cell cycle. These results suggest that the two distinct complexes are involved in different aspects of mitotic chromosome organization in human cells.
Synonyms	SMC protein 2, SMC-2, SMC2L1, CAP-E, Chromosome-associated protein E, XCAP-E homolog
Reference Data

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