PTGER3 Mouse Monoclonal Antibody [Clone ID: 5F5]

Specifications

Product Data
Clone Name	5F5
Applications	WB
Recommend Dilution	Western Blot (1-5 µg/ml). Positive Control: Porcine brain lysate.
Reactivity	Bovine, Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human EP3 receptor protein and mouse myeloma cells.
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	prostaglandin E receptor 3
Database Link	Entrez Gene 5733 Human UniProt ID P43115
Background	Prostaglandins (PG's) are produced by the metabolism of arachidonic acid. PGE-2 is one of the five physiologically significant prostanoids known. It’s wide spectrum of physiologic and pharmacologic effects in various tissues are mediated through binding to the PGE-2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP3 receptors are 365-425 amino acid proteins. There are currently 4 known isoforms of EP3 receptors named EP3A, 3B, 3C and 3D. Each of has different physiological function, but differ only in the carboxyl terminus and how they couple to their respective G-proteins. EP3 receptors are involved in water absorption, gastric acid secretion, uterine contraction, neurotransmitter release and the hydrolysis of fat cells (lipolysis). EP3 receptors also act as a mediator of neural inflammation. These receptors are mainly localized in the brain, kidney, stomach, uterus and ovaries.
Synonyms	Prostaglandin E receptor 3, Prostanoid EP3 receptor, PGE2 receptor EP3 subtype, PGE2-R, PGE receptor EP3 subtype, EP3-III, EP3-II, EP3, Prostaglandin E2 receptor EP3 subtype
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.