Cytochrome P450 1A2 (CYP1A2) Mouse Monoclonal Antibody [Clone ID: 3B8C1]

Specifications

Product Data
Clone Name	3B8C1
Applications	IHC, WB
Recommend Dilution	Western Blot: 1 - 2 µg/ml. Immunohistochemistry: 1 - 5 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with rat cytochrome p450 proteins and mouse myeloma Ag8563 cells.
Specificity	This antibody reacts to Cytochrome P450 1A2.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	cytochrome P450 family 1 subfamily A member 2
Database Link	Entrez Gene 1544 Human UniProt ID P05177
Background	P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. NADPH cytochrome 450 reductase is a microsomal enzyme responsible for the transfer of electrons from NADPH to cytochrome P450 enzymes during the P450 catalytic cycle. NADPH cytochrome P450 reductase is localized to the endoplasmic reticulum where it is also able to transfer electrons to heme oxygenase and cytochrome β5. NADPH cytochrome P450 reductase is structurally related to two separate flavoprotein families, ferredoxin nucleotide reductase (FNR) and flavodoxin. Electron transfer of NADPH cytochrome P450 reductase requires the binding of two flavin cofactors, FAD and FMN, to the FNR and flavodoxin domains, respectively.
Synonyms	Cytochrome P450 1A2, CYPIA2, Cytochrome P450-P3, Cytochrome P(3)450, Cytochrome P450 4
Reference Data

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