TCP1 beta (CCT2) Mouse Monoclonal Antibody [Clone ID: F39 P7 F11]

Specifications

Product Data
Clone Name	F39 P7 F11
Applications	IHC, WB
Recommend Dilution	Western Blot: 1-2 µg/ml. Immunohistochemistry on Formlin-Fixed, Paraffin-Embedded Tissue Sections: 1-5 µg/ml. Positive Control: Colorectal cancer tissue, Calu6 and HT29 cell lysates.
Reactivity	Frog, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminal of the TCP1 beta protein and Mouse myeloma Ag8563 cells.
Specificity	This antibody recognizes T-Complex Protein 1, beta subunit.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Protein A/G Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	57 kDa
Gene Name	chaperonin containing TCP1 subunit 2
Database Link	Entrez Gene 10576 Human UniProt ID P78371
Background	The protein TCP-1 (t-complex polypeptide 1) is a subunit of the hetero-oligomeric complex CCT (chaperonin containing TCP-1) present in the eukaryotic cytosol. The CCT of eukaryotic cytosol is composed of eight different subunit species that are proposed to have independent functions in folding its in vivo substrates, the Actins and Tubulins. TCP-1 was first identified in the mouse as relevant for tail-less and embryonic lethal phenotypes. Sequences homologous to TCP-1 have been isolated in several other species, and the yeast TCP-1 has been shown to encode a molecular chaperone for Actin and Tubulin. TCP-1 found in mammalian cells and yeast plays an important role in the folding of cytosolic proteins.
Synonyms	99D8.1, CCT-beta, CCTB, TCP-1 beta
Reference Data

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