alpha 1 Fetoprotein (AFP) Mouse Monoclonal Antibody [Clone ID: MBS-12]

Specifications

Product Data
Clone Name	MBS-12
Applications	ELISA, IHC
Recommend Dilution	MBS-12 can be applied for detection of AFP on ELISAs and Immunohistochemistry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Alpha-fetoprotein (AFP). Spleen cells from immunised BALB/c mice were fused with cells of the NS1 myeloma cell line.
Specificity	This antibody clone MBS-12 specifically detects AFP, an important oncodevelopmental gene product, also expressed in adults during liver regeneration and hepatocarcinogenesis.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	alpha fetoprotein
Database Link	Entrez Gene 174 Human UniProt ID P02771
Background	Alpha Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. alpha Fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha Fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha Fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. alpha Fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha Fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Synonyms	Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP
Reference Data

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