CD62P (SELP) Mouse Monoclonal Antibody [Clone ID: Psel.KO.2.5]

Specifications

Product Data
Clone Name	Psel.KO.2.5
Applications	FC, IHC, IP
Recommend Dilution	Immunoprecipitation. Flow Cytometry: Use 10 µl of 1/1-1/50 diluted antibody to label 10e6 cells in 100 µl. Immunohistochemistry on Paraffin Sections: 10 µg/ml (Heat induced antigen retrieval in pH 6.0 citrate buffer is recommneded).
Reactivity	Human, Porcine, Sheep
Host	Mouse
Clonality	Monoclonal
Immunogen	CD62P transfected 300.19 cells.
Specificity	This antibody recognises the CD62P cell surface antigen, a 140kD glycoprotein also known as P-selectin.
Formulation	PBS, pH 7.4 State: Purified State: Liquid purified IgG fraction from Ttissue Culture Supernatant Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	selectin P
Database Link	Entrez Gene 6403 Human UniProt ID P16109
Background	SELP encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. CD62P is expressed by activated platelets and endothelial cells, and plays an important role in adhesive processes between leucocytes and endothelial cells.
Synonyms	SELP, GMRP, GRMP, PADGEM, GMP-140, LECAM3
Reference Data

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