LILRB1 Mouse Monoclonal Antibody [Clone ID: 4F9]

Specifications

Product Data
Clone Name	4F9
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/50-1/200 diluted CD85j antibody to label 1x10e6 cells in 100 µl. Immunohistochemistry on Frozen Sections: 1/100. Positive Control: Human Tonsil.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Monocyte derived dendritic cells.
Specificity	This antibody is specific for CD85j, a member of the leukocyte immunoglobulin-like receptor (LIR) family.
Formulation	PBS State: Purified State: Liquid purified IgG fraction from tissue culture supernatant Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	leukocyte immunoglobulin like receptor B1
Database Link	Entrez Gene 10859 Human UniProt ID Q8NHL6
Background	This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. CD85j is a receptor for MHC Class I molecules and ligand binding results in inhibitory signals and down-regulation of the immune response.CD85j is expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells, T-cells and natural killer (NK) cells.
Synonyms	LILR-B1, ILT2, LIR1, MIR7, LIR-1, ILT-2, MIR-7
Reference Data

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