TRF1 (TERF1) Mouse Monoclonal Antibody [Clone ID: BED5]

CAT#: AM05622PU-N

TRF1 (TERF1) mouse monoclonal antibody, clone BED5, Purified



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CNY 4,587.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name BED5
Applications ELISA, IHC, WB
Recommend Dilution ELISA.
Western Blot: Detects a band of approximately 60kDa in Jurkat whole cell lysates.
Immunohistochemistry on Frozen Sections.
Immunohistochemistry on Paraffin Sections:
1/200-1/1000. Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant TRF1
Specificity This antibody recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kDa protein.
Formulation PBS pH 7.4 containing 0.09% Sodium Azide as preservative
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Affinity chromatography on Protein G
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name telomeric repeat binding factor 1
Background Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage.
TRF1 is thought to play a role in leukaemia being expressed at significantly higher levels in patients with acute lymphoblastic leukaemia than those with myeloid leukaemia.
Synonyms PIN2, TRBF1, TRF, TRF1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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