IRF3 (108-166) Mouse Monoclonal Antibody [Clone ID: 3F10]
CAT#: AM05643PU-S
IRF3 (108-166) mouse monoclonal antibody, clone 3F10, Purified
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CNY 5,630.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | 3F10 |
Applications | ELISA, FC, IF, WB |
Recommend Dilution | ELISA. Western blot (1:1000 - 1:2000), recommended starting dilution is 1:1000. Flow Cytometry. Immunoflourescence. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant human IRF3 (108-166 aa) purified from E.coli |
Specificity | The antibody recognizes human interferon regulatory factor 3 (IRF3), a 55 kDa constitutively expressed member of the IRF family. Other species not tested. |
Formulation | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein-G affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | interferon regulatory factor 3 |
Database Link | |
Background | Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta, along with other interferon-induced genes. |
Synonyms | Interferon regulatory factor 3, IRF-3 |
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