Ly6a Rat Monoclonal Antibody [Clone ID: D7]

Specifications

Product Data
Clone Name	D7
Applications	FC, IP, WB
Recommend Dilution	Western Blot. Immunoprecipitation. Flow Cytometry.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	IL-2-dependent mouse T cell line CTL-L.
Specificity	This antibody recognises members of the lymphocyte activation protein-6 (Ly6) multigene family. Specifically, it recognises Ly6A.2 and Ly6E.1. Clone D7 has been reported to induce T cell activation.
Formulation	Borate buffered saline pH8.0 containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	lymphocyte antigen 6 complex, locus A
Database Link	Entrez Gene 110454 Mouse UniProt ID P05533
Background	Ly6A/E is also known as stem cell antigen-1 (Sca-1). It is an 18kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein of the Ly6 gene family. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly6.1 and Ly6.2 allotypes. As such, it is the most common marker used for enriching adult hematopoietic stem cells. It has varied functions, it plays a role in bone formation, myoblast proliferation and differentiation and the activation and immunosuppressive function of T cells.
Synonyms	Lymphocyte antigen 6A-2/6E-1, Ly-6A.2/Ly-6E.1, T-cell-activating protein, TAP, Stem cell antigen 1, SCA-1
Reference Data

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