Nucleophosmin (NPM1) Mouse Monoclonal Antibody [Clone ID: 7H10B9]

Specifications

Product Data
Clone Name	7H10B9
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1/10000.  Western Blot: 1/500-1/2000.  Immunofluorescence: 1/200-1/1000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human NPM expressed in E. Coli.
Specificity	This antibody recognizes Human Nucleophosmin. Other species not tested.
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Database Link	Entrez Gene 4869 Human UniProt ID P06748
Background	Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Synonyms	NPM, NPM1, Numatrin
Reference Data

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