Rb (RB1) Mouse Monoclonal Antibody [Clone ID: 7E4B8]

Specifications

Product Data
Clone Name	7E4B8
Applications	ELISA, IHC
Recommend Dilution	ELISA: Propose dilution 1/10000.  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human RB expressed in E. Coli.
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	RB transcriptional corepressor 1
Database Link	Entrez Gene 5925 Human UniProt ID P06400
Background	The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
Synonyms	Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC
Reference Data

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