EIF4EBP1 Mouse Monoclonal Antibody [Clone ID: 9E12D9]

Specifications

Product Data
Clone Name	9E12D9
Applications	WB
Recommend Dilution	Western Blot: 1/500 - 1/2000. ELISA: 1/10000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of 4EBP1 expressed in E. Coli.
Specificity	Recognizes 4E-BP1
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	eukaryotic translation initiation factor 4E binding protein 1
Database Link	Entrez Gene 1978 Human UniProt ID Q13541
Background	4E-BP1 (eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Synonyms	PHAS-I, PHAS-1, PHAS1
Reference Data

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