TYRO3 Mouse Monoclonal Antibody [Clone ID: 1C10E8]

Specifications

Product Data
Clone Name	1C10E8
Applications	IF, WB
Recommend Dilution	ELISA: 1/10000.  Western Bloting: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of TYRO3 expressed in E. Coli.
Specificity	Recognizes Tyrosine Protein Kinase (TYRO3).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	TYRO3 protein tyrosine kinase
Database Link	Entrez Gene 7301 Human UniProt ID Q06418
Background	Tyrosine-Protein Kinase (TYRO3) belongs to the Tyr protein kinase family (AXL/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl). Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
Synonyms	BYK, DTK, RSE, SKY
Reference Data

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