AMACR Mouse Monoclonal Antibody [Clone ID: 2A10F3]

Specifications

Product Data
Clone Name	2A10F3
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1/10000. Western Bloting:1/500 - 1/2000 . Immunofluorescence: 1/200 - 1/1000.  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human AMACR expressed in E. Coli.
Specificity	Recognizes AMACR (alpha-methylacyl-CoA racemase).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	alpha-methylacyl-CoA racemase
Database Link	Entrez Gene 23600 Human UniProt ID Q9UHK6
Background	AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
Synonyms	Alpha-methylacyl-CoA racemase, P504S
Reference Data

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