MAP4K4 Mouse Monoclonal Antibody [Clone ID: 3C7B5]

Specifications

Product Data
Clone Name	3C7B5
Applications	WB
Recommend Dilution	Western Blot: 1/500 - 1/2000. ELISA: 1/10000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.
Specificity	Recognizes Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mitogen-activated protein kinase kinase kinase kinase 4
Database Link	Entrez Gene 9448 Human UniProt ID O95819
Background	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms	MEKKK 4, MAPK/ERK kinase kinase kinase 4, NIK
Reference Data

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